The Advanced Science & Technology Commercialization Center, better known as ASTeCC, is UK's premier entrepreneurial ecosystem business incubator that encourages early-stage, high-technological, start-up company growth that will lead to economic development opportunities for the Commonwealth.

ASTeCC is also home to faculty labs for research with commercialization potential, and shared-use facilities for the entire campus, including the Center for Nanoscale Science and Engineering, the Electron Microscopy Center and the Mass Spectrometry Facility

Located in the middle of campus within the engineering complex, ASTeCC opened in 1994. The 80,000 sq. ft., $17 million building project was funded by the Economic Development Administration and the Small Business Administration. Sixty-two companies have "graduated" from ASTeCC since 1994.